| SINDBIS病毒对宿主细胞基因表达的影响 |
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| 引用本文： | 王小忠 谢建新 许晓洁 梁凤霞 丁明孝. SINDBIS病毒对宿主细胞基因表达的影响[J]. 微生物学报, 1994, 34(5): 345-354 |
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| 作者姓名： | 王小忠 谢建新 许晓洁 梁凤霞 丁明孝 |
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| 作者单位： | 北京大学生命科学学院；北京大学生命科学学院 北京 |
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| 基金项目： | 高等学校博士学科点专项科研基金，国家自然科学基金资助项目 |
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| 摘 要： | Sindbis病毒(SBV)的感染能迅速地抑制宿主细胞的基因表达(mRNA合成与蛋白质合成),但细胞rRNA的合成水平与正常细胞接近.同时SBV还诱导产生一种细胞特异的核基质结合蛋白P105.用放线菌素D处理细胞,导致感染细胞中病毒结构蛋白的合成量及有感染力的子代病毒产量明显下降.实验结果不仅显示了SBV对宿主细胞基因表达的复杂调控关系,而且还表明SBV的非结构蛋白nsP2和衣壳蛋白C可能直接参与这一过程.
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| 关 键 词： | Sindbis病毒 基因表达 宿主 病毒 |
THE EFFECT OF SINDBIS VIRUS MULTIPLICATION ON GENE EXPRESSION OF HOST CELLS |
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| Wang Xiaozhong Xie Jianxin Xu Xiaojie Liang Fengxia Ding Mingxiao. THE EFFECT OF SINDBIS VIRUS MULTIPLICATION ON GENE EXPRESSION OF HOST CELLS[J]. Acta microbiologica Sinica, 1994, 34(5): 345-354 |
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| Authors: | Wang Xiaozhong Xie Jianxin Xu Xiaojie Liang Fengxia Ding Mingxiao |
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| Abstract: | Sindbis virus (SBV) infection mediated a rapid shutoff of host cellular gene expression (mRNA synthesis and protein synthesis); however the synthesis of cellular rRNA remained at the same level as the uninfected cells. Meanwhile a cellular protein P105 was shown to be enriched in the nuclear matrix. Actionmycin D treatment after virus infection resulted in an apparent reduce in the production of viral structural proteins and infectious virions. The results presented here not only demonstrated the complexity of SBV-mediated regulation of host gene expression,but also suggested SBV nonstructural protein nsP2 and capsid protein C were possibly involved in this process. |
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| Keywords: | Sindbis virus (SBV ) Nonstructural protein Nuclear matrix Gene expression |
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