Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging |
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Authors: | S Mukherjee A Asaithambi M K Thakur |
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Institution: | (1) Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, 221 005 Varanasi, India |
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Abstract: | We have examined the endogenous nuclease activity of the liver of intact, castrated and testosterone-treated mice of different ages. Both Mg2+- and Ca2+-dependent endogenous nuclease activities decline in old age. Withdrawal of the hormone increases nuclease activity in the immature and young. However, testosterone administration prevents the digestion of nuclei to different extents in all ages. These findings suggest a possible protective role of testosterone in the cleavage of liver chromatin by endogenous nucleases during the aging of mice. |
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Keywords: | aging androgen endogenous nuclease mice liver |
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