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| 小鼠脑内甘氨酸含量在缺氧预适应中的变化 | |
| 作者姓名： | Liu HY Lu GW |
| 作者单位： | 1. 白求恩医科大学药理室,长春,130021 2. 首都医科大学神经生物学系,北京100054 3. 白求恩医科大学第三临床医院,长春,130031 |
| 基金项目： | SupportedbytheNationalNaturalScienceFoundationofChina (No 396 70 871)andBeijingNaturalScienceFoundation (No 796 2 0 0 9) |
| 摘 要： | 在小鼠重复缺氧预适应过程中,用HPLC方法,测定其全脑与不同脑区中的甘氨酸含量。结果表明,随着动物对低氧耐受性的增高,其全脑、间脑,特别是海马、脑干中的甘氨酸含量升高。结果提示,甘氨酸作为抑制性递质对低氧预适应的形成具有正面影响。 |
| 关 键 词： | 甘氨酸 缺氧耐受性 缺氧预适应 脑区 小鼠 |
Changes in glycine content in mouse brain during hypoxic preconditioning |
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| Liu HY,Lu GW.Changes in glycine content in mouse brain during hypoxic preconditioning[J].Acta Physiologica Sinica,2001,53(6):461-464. | |
| Authors: | Liu H Y Lu G W |
| Institution: | Department of Pharmacology, Bethune Medical University, Changchun 130021, China. |
| Abstract: | Glycine content of the whole brain and subregions was measured by high pressure liquid chromatography (HPLC) in mice during their repetitive exposures to hypoxia. The contents of glycine in whole brain, diencephalon, and hippocampus and brain stem was significantly increased as the animals tolerance to hypoxia was increased. The results suggest that glycine, as an inhibitory neurotransmitter in the brain, may positively contribute to the development of hypoxic preconditioning. |
| Keywords: | glycine hypoxic tolerance hypoxic preconditioning |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |