Cellular and humoral responses to collagen-polyvinylpyrrolidone administered during short and long periods in humans |
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Authors: | Furuzawa-Carballeda Janette Rojas Emilio Valverde Mahara Castillo Irma Diaz de León Lino Krötzsch Edgar |
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Institution: | Department of Cellular Biology, Instituto de Investigaciones Biomédicas, UNAM, Ciudad Universitaria, Mexico City, Mexico. |
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Abstract: | Collagen, particularly type I, and its related derivatives have been extensively employed in many areas of pharmacology. The present study was performed to determine the safety of collagen-polyvinylpyrrolidone (collagen-PVP) by in vitro and in vivo studies. Sera and peripheral blood cells from healthy donors without treatment and patients treated with collagen-PVP were evaluated. We observed that the biodrug does not stimulate lymphoproliferation or DNA damage in vitro, nor does it induce human anti-porcine type I collagen or anti-collagen-PVP antibodies in vivo. Furthermore, no hepatic or renal metabolic dysfunctions were observed when collagen-PVP was administered by intradermal or intramuscular routes in short- or long-term treatments. In conclusion, the present work shows that no cellular damage or immunological adverse effects (cellular and humoral) occurred during collagen-PVP treatment, even after more than 400 weeks of consecutive administrations. |
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