MPEx: A tool for exploring membrane proteins |
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| Authors: | Craig Snider Sajith Jayasinghe Kalina Hristova Stephen H White |
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| Institution: | 1. Department of Physiology and Biophysics, Center for Biomembrane Systems, University of California, Irvine, California 92697‐4560;2. Department of Chemistry and Biochemistry, California State University, San Marcos, San Marcos, California 92096‐0001;3. Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 |
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| Abstract: | Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy‐plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experiment‐based physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane‐active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex . |
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| Keywords: | topology structure prediction transmembrane helices hydropathy plots hydrophobicity membrane protein explorer |
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