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Neuronal rebound spiking,resonance frequency and theta cycle skipping may contribute to grid cell firing in medial entorhinal cortex
Authors:Michael E Hasselmo
Institution:Center for Memory and Brain, Department of Psychology and Graduate Program for Neuroscience, Boston University, 2 Cummington St., Boston, MA 02215, USA
Abstract:Data show a relationship of cellular resonance and network oscillations in the entorhinal cortex to the spatial periodicity of grid cells. This paper presents a model that simulates the resonance and rebound spiking properties of entorhinal neurons to generate spatial periodicity dependent upon phasic input from medial septum. The model shows that a difference in spatial periodicity can result from a difference in neuronal resonance frequency that replicates data from several experiments. The model also demonstrates a functional role for the phenomenon of theta cycle skipping in the medial entorhinal cortex.
Keywords:grid cells  head direction  place cells  entorhinal cortex  rat  theta rhythm
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