Comparative effectiveness of antioxidant melatonin and radioprotectors indralin and phenylephrine in local radiation injuries |
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Authors: | Vasin M V Ushakov I B Kovtun V Iu Komarova S N Semenova L A Galkin A A |
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Institution: | Institute of Military Medicine, Ministry of Deferense of Russian Federation, 126083 Russia. |
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Abstract: | In experiments on mice radioprotective properties of indraline, phenyleprine and melatonin were compared at topical application as an ointment at a place of local exposure of animal hind to a dose of 38.3 Gy of 60Co gamma-quanta. Factor of dose reduction was 1.27-1.32 for indraline (1-10% ointment) and 1.29 for phenyleprine (0.25% ointment). Antioxidants were low efficient at radiation skin burn. At later local radiation injuries, such as hind contracture, the efficiency of indraline was 1.33-1.5, that of phenyleprine was 1.28, and that of melatonine (2 and 5% ointment) was 1.23-1.47. |
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