Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells |
| |
| Authors: | Lars L Eftang Ying Esbensen Tone M Tannæs Ida RK Bukholm Geir Bukholm |
| |
| Affiliation: | 1.Department of Clinical Molecular Biology (Epigen),Institute of Clinical Medicine, University of Oslo, Akershus University Hospital,L?renskog,Norway;2.Department of Gastroenterological Surgery,Akershus University Hospital,L?renskog,Norway;3.Department of Clinical Molecular Biology (Epigen),Akershus University Hospital,L?renskog,Norway;4.Institute of Clinical Medicine,Akershus University Hospital, University of Oslo,L?renskog,Norway;5.Institute of Health and Society,University of Oslo,Oslo,Norway |
| |
| Abstract: | Background The association between Helicobacter pylori infection and upper gastrointestinal disease is well established. However, only a small fraction of H. pylori carriers develop disease, and there are great geographical differences in disease penetrance. The explanation to this enigma lies in the interaction between the bacterium and the host. H. pylori Outer Membrane Phospholipase A (OMPLA) has been suggested to play a role in the virulence of this bacterium. The aim of this study was to profile the most significant cellular pathways and biological processes affected in gastric epithelial cells during 24 h of H. pylori exposure, and to study the inflammatory response to OMPLA+ and OMPLA- H. pylori variants. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
