Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota |
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Authors: | Imase Kyoto Takahashi Motomichi Tanaka Akifumi Tokunaga Kengo Sugano Hajime Tanaka Mamoru Ishida Hitoshi Kamiya Shigeru Takahashi Shin'ichi |
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Affiliation: | Third Department of Internal Medicine;, Department of Infectious Disease, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo, Japan;, Miyarisan Pharmaceutical, 1-10-3, Kaminakazato, Kita-ku, Tokyo, Japan |
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Abstract: | Antibiotic associated diarrhea due to human intestinal microbiota abnormalities is a side effect of H. pylori eradication therapy. We examined intestinal microbiota changes during H. pylori eradication therapy and the preventive effect of CBM588 as a probiotic agent. Nineteen patients with gastro-duodenal ulcer were randomly divided into three groups: group A (without probiotics), group B (with regular doses of CBM588) and group C (with double doses of CBM588). The incidence of diarrhea and soft stools during H. pylori eradication therapy was 43% in group A and 14% in group B, while none of the patients in group C reported diarrhea or soft stools. Both bacterial counts and detection rates of bifidobacteria and/or obligate anaerobe were decreased by eradication therapy. However, bacterial counts of obligate anaerobes in group C were significantly higher than in group A ( P < 0.05). Additionally, during eradication therapy C. difficile toxin A was detected in both group A and group B but not in group C. In conclusion, these results indicate that H. pylori eradication therapy induces antibiotic associated diarrhea due to abnormalities in intestinal microbiota and/or C. difficile . However, these side effects might be prevented by probiotics. |
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Keywords: | H. pylori eradication therapy C. butyricum MIYAIRI588 intestinal microbiota C. difficile |
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