On the relationship of OSW-1 to the cephalostatins |
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| Authors: | Guo C LaCour T G Fuchs P L |
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| Institution: | Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. |
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| Abstract: | Antineoplastic bis-steroidal (cephalostatin-type) analogues of the saponin OSW-1 were produced from a dihydroaglycone of OSW-1. The key aglycone 6H was obtained from 5alpha-androstan-3beta-ol-17-one in 8 steps (38% yield). The SAR of the aglycones, intermediates, and hybrid analogues provide insights regarding the proposed common role of C22-oxocarbenium ions in the bioactivity of both OSW-1 and cephalostatins. |
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