Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa |
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| Authors: | Lucy Dorrell Tao Dong Graham S Ogg Simon Lister Steve McAdam Tim Rostron Chris Conlon Andrew J McMichael and Sarah L Rowland-Jones |
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| Institution: | Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS,1. Department of Genito-Urinary Medicine, Imperial College School of Medicine, London W2 1PG,2. and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU,3. United Kingdom |
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| Abstract: | We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific. |
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