Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network |
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| Authors: | Julia von Blume Anne-Marie Alleaume Christine Kienzle Amado Carreras-Sureda Miguel Valverde Vivek Malhotra |
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| Institution: | 1.Max Planck Institute for Biochemistry, 82152 Martinsried, Germany;2.Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain;3.Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain;4.Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain;5.European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany |
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| Abstract: | Ca2+ import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca2+ retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca2+ import into the TGN; it binds secretory cargo in a Ca2+-dependent reaction and is required for its sorting at the TGN. |
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