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Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
Authors:Maia Merabishvili  Daniel De Vos  Gilbert Verbeken  Andrew M Kropinski  Dieter Vandenheuvel  Rob Lavigne  Pierre Wattiau  Jan Mast  Catherine Ragimbeau  Joel Mossong  Jacques Scheres  Nina Chanishvili  Mario Vaneechoutte  Jean-Paul Pirnay
Abstract:In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections.
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