Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV |
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| Authors: | K Nakajima O Martínez-Maza T Hirano E C Breen P G Nishanian J F Salazar-Gonzalez J L Fahey T Kishimoto |
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| Institution: | Institute for Molecular and Cellular Biology, Osaka University, Japan. |
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| Abstract: | Polyclonal B cell activation is commonly observed in AIDS and in infection with HIV. The effect of HIV on the induction of B cell stimulatory factor 2 (BSF-2) production was examined, since BSF-2 plays an essential role in the differentiation of activated B cells to Ig-secreting cells. Increased BSF-2 mRNA levels and increased BSF-2 secretion were observed soon after exposure of mononuclear cells isolated from healthy donors to both "live" and inactivated HIV. HIV-induced BSF-2 production was seen in monocyte/macrophages, but not in T cells. These results suggest that the HIV-induced overproduction of BSF-2 might contribute to the polyclonal B cell activation seen in AIDS and in infection with HIV. |
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