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SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae |
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| Authors: | Koji Masumura Sachi Matsukami Kumiko Yonekita Muneyoshi Kanai Kazunori Kume Dai Hirata |
| Institution: | 1. Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, Japan;2. National Research Institute of Brewing, Higashi-Hiroshima, Japan;3. Research and Development Department, Asahi Sake Brewing Co. Ltd., Nagaoka, Japan |
| Abstract: | ABSTRACTSko1 plays a key role in the control of gene expression by osmotic and oxidative stress in yeast. We demonstrate that the decrease in chronological lifespan (CLS) of hog1Δ cells was suppressed by SKO1 deletion. sko1Δ single mutant cells were shown to have a longer CLS, thus implicating Sko1 in the regulation of their CLS. |
| Keywords: | Saccharomyces cerevisiae Sko1 lifespan osmotic stress oxidative stress |