Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells. |
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| Authors: | M Miyazaki E Gohda S Tsuboi H Tsubouchi Y Daikuhara M Namba I Yamamoto |
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| Institution: | Department of Cell Biology, Okayama University Medical School, Japan. |
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| Abstract: | The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody. |
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