Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines |
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| Authors: | Suhara Yoshitomo Hirota Yoshihisa Nakagawa Kimie Kamao Maya Tsugawa Naoko Okano Toshio |
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| Institution: | Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. |
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| Abstract: | Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs. |
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