l-Glutamate and l-lysine: traditional products with impetuous developments |
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Authors: | L Eggeling H Sahm |
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Institution: | (1) Institut für Biotechnologie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany e-mail: l.eggeling@fz-juelich.de Tel.: +49-2461-61-5132 Fax: +49-2461-61-2710, DE |
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Abstract: | Amino acids have been produced with the aid of microorganisms for nearly 40 years now. The economic importance of these cellular
building blocks is enormous. Demand for them is rising continuously and currently more than 106 tonnes/year are required. Continual efforts to increase production performance are directed towards the microorganisms themselves,
as well as towards technical improvements of the respective processes. A special position within the amino-acid-producing
microorganisms is traditionally occupied by Corynebacterium glutamicum. Molecular research in conjunction with NMR studies of flux has revealed fascinating new properties of this particular organism,
including the existence of a new type of exporter and reverse fluxes within the anaplerosis. The knowledge gained will enable
the further improvement of production strains and furthermore extend fundamental insights into metabolite flux management
within bacteria in general.
Received: 8 December 1998 / Received revision: 1 March 1999 / Accepted: 5 March 1999 |
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