Evolutionary history and molecular epidemiology of rabbit haemorrhagic disease virus in the Iberian Peninsula and Western Europe |
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Authors: | Fernando Alda Tania Gaitero Mónica Suárez Tomás Merchán Gregorio Rocha Ignacio Doadrio |
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Institution: | 1.Dpto. Biodiversidad y Biología Evolutiva,Museo Nacional de Ciencias Naturales (CSIC),Madrid,Spain;2.Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM-JCCM),Ciudad Real,Spain;3.Dpto. Sanidad Animal, Facultad de Veterinaria,Universidad Complutense de Madrid,Madrid,Spain;4.Dpto. Ingeniería del Medio Agronómico y Forestal,Universidad de Extremadura,Plasencia,Spain |
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Abstract: | Background Rabbit haemorrhagic disease virus (RHDV) is a highly virulent calicivirus, first described in domestic rabbits in China in
1984. RHDV appears to be a mutant form of a benign virus that existed in Europe long before the first outbreak. In the Iberian
Peninsula, the first epidemic in 1988 severely reduced the populations of autochthonous European wild rabbit. To examine the
evolutionary history of RHDV in the Iberian Peninsula, we collected virus samples from wild rabbits and sequenced a fragment
of the capsid protein gene VP60. These data together with available sequences from other Western European countries, were
analyzed following Bayesian Markov chain Monte Carlo methods to infer their phylogenetic relationships, evolutionary rates
and demographic history. |
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