TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance |
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| Authors: | Song Song Qinglan Ge Sanyuan Tangb Junfeng Bi a Key Laboratory of Molecular Developmental Biology |
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| Institution: | Song Song~(a,c,1),Qinglan Ge~(a,Jinbo Wang~(a,Haiyang Chen~(a,c),Sanyuan Tang~b,Junfeng Bi~(a,Xia Li~a,Qi Xie~b,Xun Huang~(a,*) a Key Laboratory of Molecular and Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China b State Key Laboratory of Plant Genomics,China c Graduate School of Chinese Academy of Sciences,Beijing 100049,China |
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| Abstract: | TRIpartite Motif(TRIM) family proteins are ring finger domain-containing,multi-domain proteins implicated in many biological processes. Members of the TRIM-9/C-I subfamily of TRIM proteins,including TRIM-9,MIDI and MID2,have neuronal functions and are associated with neurological diseases.To explore whether the functions of C-I TRIM proteins are conserved in invertebrates,we analyzed Caenorhabditis elegans and Drosophila trim-9 mutants.C.elegans trim-9 mutants exhibit defects in the ventral guidance of herm... |
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| Keywords: | TRIM-9 Axon guidance UNC-6/Netrin UNC-40/Frazzled |
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