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Association between mitochondrial DNA haplotype compatibility and increased efficiency of bovine intersubspecies cloning |
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| Authors: | Hao Yana Zhonghai Yana Qingwen Ma Fei Jiaoa Shuzhen Huang Yitao Zeng a |
| Affiliation: | Hao Yan~a,Zhonghai Yan~a,Qingwen Ma~(a,b),Fei Jiao~a,Shuzhen Huang~(a,Fanyi Zeng~(a,b,c),Yitao Zeng~(a,*) a Shanghai Institute of Medical Genetics,Shanghai Jiao Tong University,24/1400 West Beijing Road,Shanghai 200040,China b The Key Lab of Embryo Molecular Biology,Ministry of Health,China,and Shanghai Lab of Embryo and Reproduction Engineering,China c Institute of Medical Science,Shanghai Jiao Tong University School of Medicine,280 South Chongqing Road,Shan... |
| Abstract: | Reconstructed embryos derived from intersubspecies somatic cell nuclear transfer(SCNT) have poorer developmental potential than those from intrasubspecies SCNT.Based on our previous study that Holstein dairy bovine(HD) mitochondrial DNA(mtDNA) haplotype compatibility between donor karyoplast and recipient cytoplast is crucial for SCNT embryo development,we performed intersubspecies SCNT using HD as donor karyoplast and Luxi yellow heifer(LY) as recipient cytoplast according to mtDNA haplotypes determined by... |
| Keywords: | Somatic cell nuclear transfer(SCNT) Mitochondria mtDNA haplotype Epigenetic modification Bovine Intersubspecis Intrasubspecis Developmental competence |
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