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Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26 |
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| Authors: | Hillmer Axel M Flaquer Antonia Hanneken Sandra Eigelshoven Sibylle Kortüm Anne-Katrin Brockschmidt Felix F Golla Astrid Metzen Christine Thiele Holger Kolberg Susanne Reinartz Roman Betz Regina C Ruzicka Thomas Hennies Hans Christian Kruse Roland Nöthen Markus M |
| Institution: | 1 Department of Genomics, Life and Brain Center, University of Bonn, D-53127 Bonn, Germany 2 Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany 3 Department of Dermatology, University of Düsseldorf, D-40225 Düsseldorf, Germany 4 Cologne Center for Genomics, Division of Dermatogenetics, University of Cologne, D-50674 Cologne, Germany 5 Institute of Human Genetics, University of Bonn, D-53111 Bonn, Germany 6 Department of Dermatology, Ludwig Maximilians University, D-80337 Munich, Germany 7 Center for Molecular Medicine Cologne, University of Cologne, D-50931Cologne, Germany |
| Abstract: | Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss. |
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