A theory of hippocampal memory based on theta phase precession |
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Authors: | Yoko Yamaguchi |
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Institution: | (1) RIKEN Brain Science Institute (BSI), 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan; College of Science and Engineering, Tokyo Denki University; CREST Japan Science and Technology Corporation, JP |
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Abstract: | The neural dynamics of the hippocampal network for memory encoding of novel temporal sequences is proposed based on the theta
rhythm modulated firing of place cells called theta phase precession. It is hypothesized that theta phase precession is generated
at the entorhinal cortex by phase locking between local field theta oscillation and neural oscillators and that the hippocampal
closed network with feedforward and backward projections employ theta phase precession to create selectivity in the associative
connections needed for temporal sequence storage. Our analyses and computer experiments reveal that the phase precession generated
by phase locking instantaneously endows stable phase relations among neural activities in the successively changing neural
population. It is concluded that theta phase precession provides biologically plausible dynamics for the memory encoding of
novel temporal sequences as episodic events.
Received: 18 December 2002 / Accepted: 18 March 2003 /
Published online: 20 May 2003
Correspondence to: Y. Yamaguchi (e-mail: yokoy@brain.riken.go.jp, Fax: +81-48-4676938)
Acknowledgements. The author would like to express acknowledgement to Drs. McNaughton and Skaggs for their discussion and comment and to Dr.
Amari for his continuous encouragement. Further thanks are given to Mr. Haga and Dr. Wu for their discussion and cooperation. |
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Keywords: | |
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