Synthesis of monomers bearing at the 2'-position cyanomethoxycarbonyl group for phosphoramidite oligonucleotide synthesis |
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Authors: | Vasilyeva Svetlana V Abramova Tatyana V Silnikov Vladimir N |
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Institution: | Novosibirsk Institute of Bioorganic Chemistry, Novosibirsk, Russia. vasilieva_2001@ngs.ru |
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Abstract: | A novel series of phosphoroamidites for the synthesis of 2-modified oligonucleotides was designed and synthesized on the base of 2'-amino uridine and 2'-amino arabinoadenosine. The amino groups in these compounds were acidified by bis-cyanomethyl esters of different dicarbonic acids. Generated reactive linker groups containing cyanomethoxycarbonyl groups are stable under conditions of oligonucleotide synthesis but could be easily functionalised in post-synthetic stage by treatment with compounds bearing primary amino groups. |
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