Imprinting evolution and human health |
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Authors: | Radhika Das Daniel D Hampton Randy L Jirtle |
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Institution: | 1. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA 2. University Program in Genetics and Genomics, Duke University Medical Center, Durham, NC, 27710, USA 3. Department of Gastroenterology, Duke University Medical Center, Durham, NC, 27710, USA 4. Department of Radiation Oncology, Duke University Medical Center, P. O Box 3433, Durham, NC, 27710, USA
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Abstract: | Genomic imprinting results in parent-of-origin-dependent, monoallelic expression of genes. The functional haploid state of these genes has far-reaching consequences. Not only has imprinting been implicated in accelerating mammalian speciation, there is growing evidence that it is also involved in the pathogenesis of several human conditions, particularly cancer and neurological disorders. Epigenetic regulatory mechanisms govern the parental allele-specific silencing of imprinted genes, and many theories have attempted to explain the driving force for the evolution of this unique form of gene control. This review discusses the evolution of imprinting in Therian mammals, and the importance of imprinted genes in human health and disease. |
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