A purine permease in Candida glabrata |
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| Authors: | Soma Sen Gupta,David Kerridge,Marie-rené e Chevallier |
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| Affiliation: | Yale University School of Medicine, Department of Genetics, 333 Cedar St. P.O. Box 3333, New Haven, Connecticut 06510-8005, USA; Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge, UK; URA-GEM (D1481), Institut de Botanique, 28 Rue Goethe, 67 083 Strasbourg, France |
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| Abstract: | Abstract Competition experiments revealed that adenine and guanine were transported by a purine permease in both Candida glabrata 4 and a C. glabrata 4 cytosine permease negative mutant. The C. glabrata 4 cytosine permease negative mutant was isolated using 5-fluorocytosine selection. This mutant no longer transported cytosine, but transported adenine and guanine. A transport system for hypoxanthine was not detected. Hence, in addition to the cytosine permease, a purine permease exists in C. glabrata . This differs from the purine cytosine permeases in Saccharomyces cereuisiae and Candida albicans which transport adenine, cytosine, guanine and hypoxanthine. |
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| Keywords: | Candida albicans Candida glabrata Permease |
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