| Abstract: | A study was made of brain neurite-stimulating proteins separated from lysosomal fractions of mammalian brain tissue. This protein stimulates axonal growth in sensory neurons in organotypic spinal ganglia culture. The physicochemical properties of neurite-stimulating protein differs from nerve growth factor — the familiar neurotrophic factor. Findings showed that nerve growth factor antiserum does not block the action of this protein. Accordingly, brain neuritestimulating protein separated in highly purified form was found to be a low molecular weight protein with the properties of nerve growth promoting factor. It can also be used in the study of conditions promoting sensory neuron ontogenesis and for stimulating regenerative processes within the nervous system.I. P. Kovlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. O. O. Zhdanov State University, Leningrad. Translated from Neirofiziologiya, Vol. 20, No. 1, pp. 15–20, January–February, 1988. |
