The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death |
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Authors: | Nicotera Pierluigi Bano Daniele |
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Affiliation: | MRC Toxicology Unit, University of Leicester, Lancaster Road, LE1 9HN Leicester, UK. |
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Abstract: | In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons. |
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