Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists |
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| Authors: | Grasso Silvana Micale Nicola Zappalà Maria Galli Alessandro Costagli Chiara Menniti Frank S De Micheli Carlo |
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| Affiliation: | Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata, 98168 Messina, Italy. |
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| Abstract: | A selected set of 1-aryl-7,8-methylenedioxy-2,3-benzodiazepin-4-ones and their analogues were evaluated for their ability to bind the competitive and noncompetitive sites of the AMPA receptors complex as well as to the glycine site of the NMDA receptors. The results put in evidence that most of the test compounds, despite a close structural similarity with GYKI 52466, possess a significantly different pharmacological profile. |
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