Building quantitative relationship between changed sequence and changed oxygen affinity in human hemoglobin beta-chain |
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| Authors: | Wu Guang Yan Shaomin |
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| Affiliation: | Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China. hongguanglishibahao@yahoo.com |
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| Abstract: | 244 point mutations have been recorded in human hemoglobin beta-chain, of which some change the oxygen affinity of human hemoglobin beta-chain. We use the amino-acid distribution probability to quantify these mutations, and use the cross-impact analysis with Bayes' law to determine the probability that changes the oxygen affinity of human hemoglobin beta-chain under mutations. |
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