mAtNOS1 regulates mitochondrial functions and apoptosis of human neuroblastoma cells |
| |
| Authors: | Mordhwaj S. Parihar Arti PariharZhonghai Chen Rafal NazarewiczPedram Ghafourifar |
| |
| Affiliation: | Department of Surgery, Davis Heart & Lung Research Institute and Institute of Mitochondrial Biology, The Ohio State University, Columbus, Ohio, USA |
| |
| Abstract: | mAtNOS1 is a novel gene recently reported in mammalian cells with functions that are not fully understood. The present study generated human neuroblastoma SHSY cells over- and underexpressing mAtNOS1 and shows that mAtNOS1 is involved in regulating mitochondrial nitric oxide, mitochondrial transmembrane potential, protein tyrosine nitration, cytochrome c release, and apoptosis of those cells. |
| |
| Keywords: | mAtNOS1, mammalian ortholog of Arabidopsis thaliana nitric oxide synthase NO, nitric oxide Δψ, transmembrane potential DAF-2DA, 4,5 diaminofluorescein diacetate TMRM, tetramethyl rhodamine methyl ester FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone FL, 2-{2-chloro-6-hydroxy-5[(2-methyl-quinolin-8-ylamino)-methyl]-3-oxo-3H-xanthen-9-yl}-benzoic acid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
