Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate |
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| Authors: | Yuanqing Zhang Yanhong Sun Xiaoping Xu Hua Zhu Liliang Huang Xuezhu Zhang Yujin Qi Yu-Mei Shen |
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| Institution: | 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 2019 BaoJia Road, Shanghai 201800, PR China;2. Graduate School of the Chinese Academy of Sciences, 19 YuQuan Road, Beijing 100049, PR China;3. Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China |
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| Abstract: | Acetylated (Ac) dendrimer poly(amido)-amine (PAMAM) generation 5 (G5) reacted with folic acid (FA), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of Ac-G5-FA-1B4M DTPA which was further radiolabeled with 99mTc. The radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study. |
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