Practical and efficient synthesis of pyrano[3,2-c]pyridone,pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents |
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| Authors: | Xuesen Fan Dong Feng Yingying Qu Xinying Zhang Jianji Wang Philippe M Loiseau Graciela Andrei Robert Snoeck Erik De Clercq |
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| Institution: | 1. School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, PR China;2. Chimiothérapie Antiparasitaire, UMR-CNRS 8076, Université Paris-Sud, 92290 Chatenay, Malabry F-92290, France;3. Rega Institute for Medical Research, Katholieke Universiteit Leuven 3000, Leuven, Belgium |
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| Abstract: | A highly practical and efficient preparation of pyrano3,2-c]pyridone and pyrano4,3-b]pyran derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of aldehyde (1), 4-hydroxy-pyridin-2(1H)-one or 4-hydroxy-2-pyranone (2), and malononitrile (3). As an application, a series of pyrimidine nucleoside-pyrano3,2-c]pyridone or pyrano4,3-b]pyran hybrids were efficiently obtained. These hybrid compounds were evaluated as potential antiviral and antileishmanial agents and showed encouraging biological activities. |
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