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Substituted tetrahydro-β-carbolines as potential agents for the treatment of human papillomavirus infection |
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| Authors: | John F Miller Elizabeth M Turner Ronald G Sherrill Kristjan Gudmundsson Andrew Spaltenstein Phiroze Sethna Kevin W Brown Robert Harvey Karen R Romines Pamela Golden |
| Institution: | 1. Department of Medicinal Chemistry, Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA;2. Department of Virology, Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA;3. Department of DMPK, Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA |
| Abstract: | The identification and optimization of a series of substituted tetrahydro-β-carbolines with potent activity against human papillomavirus is described. Structure–activity studies focused on the substitution pattern and chirality of the β-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range. |
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