Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs |
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| Authors: | Kouatli Omar Athina Geronikaki Panagiotis Zoumpoulakis Charalabos Camoutsis Marina Soković Ana Ćirić Jasmina Glamočlija |
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| Affiliation: | 1. School of Pharmacy, Department of Pharmaceutical Chemistry of Aristotle, University of Thessaloniki, Thessaloniki, Greece;2. Laboratory of Molecular Analysis, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vas. Constantinou Avenue, 11635 Athens, Greece;3. School of Health Sciences, Department of Pharmacy, Laboratory of Pharmaceutical Chemistry, University of Patras, Patras, Greece;4. Department of Plant Physiology, Mycological Laboratory, Institute of Biological Research, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia |
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| Abstract: | As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs. |
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