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Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers |
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| Authors: | John Lloyd Heather J. Finlay Wayne Vacarro Tram Hyunh Alexander Kover Rao Bhandaru Lin Yan Karnail Atwal Mary Lee Conder Tonya Jenkins-West Hong Shi Christine Huang Danshi Li Huabin Sun Paul Levesque |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA |
| Abstract: | Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development. |
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