Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds,and evaluation of in vivo analgesic activity |
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| Authors: | Yoo Lim Kam Hee-Kyung Rhee Hyewhon Rhim Seung Keun Back Heung Sik Na Hea-Young Park Choo |
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| Affiliation: | 1. School of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea;2. Department of Biological Science, Sookmyung Women’s University, Seoul 140-742, Republic of Korea;3. Life Sciences Division, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea;4. Department of Physiology, Korea University College of Medicine, Seoul 136-705, Republic of Korea |
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| Abstract: | Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. |
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