Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis,biological evaluation and docking studies |
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| Authors: | Anasuya Sahoo Samiye Yabanoglu Barij N Sinha Gulberk Ucar Arijit Basu Venkatesan Jayaprakash |
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| Institution: | 1. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215, India;2. Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, 06100 S?hh?ye, Ankara, Turkey |
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| Abstract: | Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values. |
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