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Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc |
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| Authors: | Rémy C. Lemoine Ann C. Petersen Lina Setti Thomas Baldinger Jutta Wanner Andreas Jekle Gabrielle Heilek André deRosier Changhua Ji David M. Rotstein |
| Affiliation: | 1. Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA;2. Department of Viral Diseases, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA |
| Abstract: | The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc. |
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