Two novel neo-clerodane diterpenoids from Scutellaria barbata |
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| Authors: | Hanna Lee YuJin Kim Inho Choi Byung Sun Min Sang Hee Shim |
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| Institution: | 1. School of Biotechnology, Yeungnam University, 214-1 Dae-dong, Gyeongsan, Gyeongbuk 712-749, South Korea;2. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, South Korea |
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| Abstract: | Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC50 value of 41.4 μΜ. |
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