New antifungal peptides. Synthesis,bioassays and initial structure prediction by CD spectroscopy |
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| Authors: | Mónica S. Olivella Ana M. Rodríguez Susana A. Zacchino Csaba Somlai Botond Penke Victor Farkas András Perczel Ricardo D. Enriz |
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| Affiliation: | 1. Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, 5700 San Luis, Argentina;2. Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina;3. Department of Medical Chemistry, University of Szeged, Dóm ter 8, H-6720 Szeged, Hungary;4. HAS-ELU Protein Modelling Group, Institute of Chemistry, Eötvös L. University Pázmány P. s. 1/a Budapest, Hungary |
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| Abstract: | The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK-NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods. |
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