Lactarane sesquiterpenoids from Lactarius subvellereus and their cytotoxicity |
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| Authors: | Ki Hyun Kim Hyung Jun Noh Sang Un Choi Ki Moon Park Soon-Ja Seok Kang Ro Lee |
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| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea;2. Korea Research Institute of Chemical Technology, Taejeon 305-600, Republic of Korea;3. Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon 440-746, Republic of Korea;4. Division of Applied Microbiology, RDA, National Institute of Agricultural Science and Technology, Suwon 441-707, Republic of Korea |
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| Abstract: | Subvellerolactones B (1), D (2), and E (3), structurally unusual lactarane sesquiterpenoids, were isolated from the fruiting bodies of Lactarius subvellereus together with four known lactarane sesquiterpenes (4–7). The chemical structures and stereochemistries of compounds 1–3 were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments and a convenient Mosher ester procedure. Subvellerolactone B (1) exhibited cytotoxicity against the A549, SK-MEL-2, and HCT-15 cell lines with IC50 values of 26.5, 18.3, and 14.2 μM, respectively, and subvellerolactones D (2) and E (3) showed cytotoxicity against the A549 and HCT-15 cell lines (IC50 (2): 25.1 and 17.8 μM, and IC50 (3): 19.6 and 28.7 μM, respectively). |
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