7′,8′-Dihydroobolactone,a typanocidal α-pyrone from the rainforest tree Cryptocarya obovata |
| |
| Authors: | Rohan A Davis Ozlem Demirkiran Melissa L Sykes Vicky M Avery Lekha Suraweera Gregory A Fechner Ronald J Quinn |
| |
| Institution: | 1. Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia;2. Department of Chemistry, Faculty of Science and Arts, Trakya University, Edirne 22030, Turkey |
| |
| Abstract: | Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
