Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit |
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| Authors: | Kristopher E Boyle Karen S MacMillan David A Ellis James P Lajiness William M Robertson Dale L Boger |
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| Institution: | Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA |
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| Abstract: | The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropac]oxazolo2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit. |
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