Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists |
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| Authors: | Paul Eastwood Jacob Gonzalez Sergio Paredes Arsenio Nueda Teresa Domenech Joan Alberti Bernat Vidal |
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| Institution: | Almirall Research Center, Almirall S.A., Ctra. Laureà Miró 408, St. Feliu de Llobregat, E-08980 Barcelona, Spain |
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| Abstract: | The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A2B adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat. |
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