Synthesis and biological activity of 2-hydroxynicotinoyl-serine-butyl esters related to antibiotic UK-3A |
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| Authors: | Ade Arsianti Muhammad Hanafi Endang Saepudin Tsumoru Morimoto Kiyomi Kakiuchi |
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| Affiliation: | 1. Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Takayama-cho, Ikoma, Nara 630-0192, Japan;2. LIPI Research Center for Chemistry, Kawasan Puspiptek, Tangerang, Banten, Indonesia;3. Department of Chemistry, Faculty of Mathematics and Science, University of Indonesia, Depok, Indonesia |
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| Abstract: | Novel 2-hydroxynicotinoyl-serine-butyl esters have been synthesized. Three-step reactions from l-serine by esterification with n-butanol, amidation with 2-hydroxynicotinic acid and esterification with the corresponding carboxylic acids gave AD-1, AD-2 and AD-3. The toxicity level of esters were determined by Brine shrimp assay, and antibiotic activity was tested against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Candida albicans. AD-3 showed greater activity as a growth inhibitor of B. subtilis and S. aureus compared to Antimycin A3. |
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