Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents |
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| Authors: | Hamid Irannejad Mohsen Amini Fariba Khodagholi Niloufar Ansari Solaleh Khoramian Tusi Mohammad Sharifzadeh Abbas Shafiee |
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| Institution: | 1. Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran;2. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176, Iran;4. Department of Medicinal Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research center, Tehran University of Medical Sciences, Tehran 14176, Iran |
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| Abstract: | The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-κB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases. |
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