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2,5-Disubstituted pyridines as potent GPR119 agonists |
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| Authors: | Yulin Wu Judith D. Kuntz Andrew J. Carpenter Jing Fang Howard R. Sauls Daniel J. Gomez Carina Ammala Yun Xu Shane Hart Sarva Tadepalli |
| Affiliation: | GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA |
| Abstract: | A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. |
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