Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists

Authors:	Reema K Thalji Nambi Aiyar Elizabeth A Davenport Joseph A Erhardt Lorena A Kallal Dwight M Morrow Shobha Senadhi Cynthia L Burns-Kurtis Joseph P Marino

Institution:	1. Department of Chemistry, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;2. Department of Biology, Metabolic Pathways Centre for Excellence in Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA;3. Department of Biological Reagents and Assay Development, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;4. Cancer Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;5. Stem Cell Discovery Performance Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;6. Department of Chemistry, Metabolic Pathways Centre for Excellence in Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA

Abstract:	Benzofuran-substituted urea analogs have been identified as novel P2Y₁ receptor antagonists. Structure–activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.

Keywords:
本文献已被 ScienceDirect 等数据库收录！