Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii |
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| Authors: | Anil Kanaujia Rajeev Duggar Steve Thomas Pannakal Satyapal Singh Yadav Chandra Kant Katiyar Vinay Bansal S Anand S Sujatha BS Lakshmi |
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| Institution: | 1. New Drug Discovery Research, Ranbaxy Research Labs, R&D-III, Plot no. 20, Sector 18, Udyog Vihar Industrial Area, Gurgaon, Haryana, India;2. Center for Biotechnology, Anna University, Chennai, India |
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| Abstract: | Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10 ng/ml and 100 ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells. |
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